50,000 people with Barrett's Oesophagus will progress to Cancer 

  Late Diagnosis costs Lives

Grand Challenge - Cancer Research & HCUK

Heartburn Cancer Uk Founder To Be Part Of Cancer Research Uk’s Grand Challenge Helping To Answer Cancer’s Biggest Questions Heartburn Cancer UK’S founder, Mimi McCord, has been announced as a member of one of the first global research teams to be recipients of Cancer Research UK’s £20m Grand Challenge award.

CRUK hopes to uncover some of the unknown causes of cancer.

CRUK picture
Maggie (left) and Mimi (right) at the entrance to the Franklin-Wilkins building, King’s College London
(Picture courtesy of CRUK)

Mimi McCord is part of the team led by Professor Sir Mike Stratton at the Wellcome Trust Sanger Institute with collaborators from France, the USA and UK. Her role within the team as patient advocate will ensure the interests and concerns of patients and their families are represented and that patients and the public have opportunities to engage with the project.

Professor Rebecca Fitzgerald Trustee & Director of HCUK is also a collaborator on the Grand Challenge.

" I am delighted to be part of such an incredible piece of groundbreaking science, which will revolutionise our understanding of cancer, our Charity HCUK is fully behind this initiative, "
Mimi McCord - HCUK

Cancer Research UK Announces Inaugural Grand Challenge Teams To Answer The Biggest Questions In Cancer
Cancer Research UK today (Friday) announces that four international teams are the first recipients of its global £100m Grand Challenge competition, which aims to overcome the biggest challenges facing cancer researchers in a global effort to beat cancer sooner.

This new Cancer Research UK initiative has been overseen by a panel of world-leading researchers*, chaired by Dr Rick Klausner, former director of the U.S. National Cancer Institute.

The winning projects are set to revolutionise our understanding of cancer, and enable us to better prevent, diagnose and treat the disease in the future. The international, multidisciplinary teams will be using unparalleled approaches to help develop pioneering solutions to some of cancer’s major challenges.

The four winning teams will:
Study cancer samples from five continents to understand the DNA damage associated with different cancers, to understand what causes them and if they can be prevented. The project will be led by Professor Sir Mike Stratton at the Wellcome Trust Sanger Institute, Cambridge, with collaborators from France, the USA and UK.

Distinguish between those women with DCIS (a condition that can develop into breast cancer) who need treatment and those who don’t, to reduce overtreatment of the condition. This project will be led by Dr Jelle Wesseling at the Netherlands Cancer Institute with collaborators from the USA, UK and Netherlands.

Develop a way to combine new and existing technologies to create virtual representations of tumours, and a global database that catalogues their genetic make-up and metabolism, which could lead to new ways to diagnose and treat the disease. This project will be led by Dr Josephine Bunch at the National Physical Laboratory, London, with collaborators from multiple UK research centres.

Create a virtual reality 3D tumour map which will allow scientists and doctors to examine – for the first time and in unprecedented detail – the cellular and molecular make-up of a patient’s entire tumour to improve diagnosis and treatment for the disease. This project will be led by Professor Greg Hannon at the University of Cambridge, with collaborators from Switzerland, Ireland, Canada, the USA and UK.

Grand Challenge

Sir Harpal Kumar, Cancer Research UK’s chief executive, said: “Cancer Research UK set up the Grand Challenge awards to bring a renewed focus and energy to the fight against cancer. We want to shine a light on the toughest questions that stand in the way of progress. We’re incredibly excited to be able to support these exceptional teams as they help us achieve our ambition.

“Cancer is a global problem, and these projects are part of the global solution. Together, we will redefine cancer – turning it from a disease that so many people die from, to one that many people can live with. We will reduce the number of people worldwide affected by cancer and achieve our goal of beating cancer sooner.”

Cancer Research UK set up Grand Challenge in 2015 and committed up to £100m to this new approach to help increase the pace of research.

To help decide the specific challenges that could transform progress against cancer, Cancer Research UK brought together some of the brightest minds and passionate voices in cancer research from across the world.

These included cancer researchers, doctors, engineers, physicists, behavioural scientists, epidemiologists, technologists and patients.

This process helped identify the big, intractable issues in cancer research, before the advisory panel of international experts reviewed and distilled them down into concrete, manageable challenges.

Seven grand challenges** were then announced, each of which identified some of the greatest barriers preventing progress in cancer research.

The international research community were asked to form multidisciplinary teams and submit proposals to answer the challenges.

In February 2016, high quality applications were submitted from more than 200 institutes, spanning 25 countries, uniting more than 400 world-class research groups.

Originally, the plan was for Grand Challenge to fund one new team every year for five years, with each team receiving up to £20m over five years for their research. But, the exceptional quality of the teams and their submissions meant that there were several proposals the panel were felt to be too important not to fund.

Cancer Research UK has now secured a partnership with the Dutch Cancer Society and an anonymous overseas donor to enable a total of four proposals to be funded. As a result, the commitments in the first round of Grand Challenge funding will now be up to £71m***. Phase two of Grand Challenge, when Cancer Research UK plans to issue a set of revised challenges, will launch this summer.

Dr Rick Klausner, chair of the Grand Challenge advisory panel and former director of the National Cancer Institute, said: “When we began the Grand Challenge we sought scientific adventurers - people willing to come together in new ways, to think differently, and bring novel approaches to answer the big questions in cancer. These unique teams have done just that.

“Cancer is a complex, and often brutal disease. Cancer Research UK’s Grand Challenge is helping us change the way we to tackle it – bringing together different disciplines, ideas, and people on a global scale. We've got our sights set on the horizon of discovery, and I’m confident these Grand Challenge teams will lead to life-changing results.”

Cancer Research UK sets out latest £20m Grand Challenges to beat cancer sooner
Cancer Research UK today (Thursday) launches the second phase of its global Grand Challenge by announcing eight new questions* – identified as some of the biggest barriers to making progress against cancer – and inviting the world’s top scientists to come together with new proposals to tackle them.

"By bringing together some of the world’s leaders in cancer research we’ve come up with eight key challenges that, if answered, could see research leap ahead at new speeds." - Sir Harpal Kumar, Cancer Research UK

Grand Challenge - the most ambitious cancer research grant in the world - is a series of £20million awards over five years. The funding provides international research teams the freedom and incentive to try new approaches, at large scale, to pursue life changing discoveries.

Understanding the biology and genetics of cancer, and how to better prevent, diagnose and treat the disease are all areas covered by the eight questions.

For more information
International press release
Grand Challenge website

For more information about Cancer Research UK’s Grand Challenge visit

Why Heartburn Cancer UK Exists

As a recognised and trusted authority in the field of Cancer of the Oesophagus, we know that with your help we can make significant inroads in the Prevention, Detection and Treatment of this disease by focussing on 5 key areas of action:  


Education leads to a lasting change. We are working hard to influence public and social policy, to lobby politicians, to campaign for change, to promote greater collaboration amonsgt the medical profession, the public and the government. We are already in the process of developing a network of effective partnerships with businesses, the pharmaceutical industry, medical professionals and other like-minded groups. We intend to affect change and influence how this disease is perceived, detected, diagnosed and treated.


Our aim is to significantly reduce incurable oesophageal cancer in the UK.

Our renowned medical professionals, all experts in the field of oesophageal cancer, will continue to play a key role in research and trials designed to reduce the incidence of this appalling disease.


Early detection rates are vital to ensure a positive outcome. We are creating a communication network to facilitate greater awareness of the importance of diagnosing the disease early, identifying the symptoms associated with the disease and seeking medical help quickly. Oesophageal cancer affects everyone regardless of their race, gender or age.


We will ensure consistent support is available to everyone affected by Barrett’s Oesophagus, regardless of who they are and where they live. Information and advice is available to all those affected by the disease and to the people who support them on our website or by telephone.

We need your help to bring this to the attention of your employees, friends & family or indeed anyone who might suffer from persistent heartburn!

You can make a difference perhaps you know someone who has suffered from persisitent heartburn, Barrett’s Oesophagus or Oesophageal Cancer. Perhaps you run an organisation and would like to help, why not make it your company’s corporate responsibility?


We are not content with standing still, we are determined to develop and grow a sustainable UK charity which continually re-invests to maximise the impact of its resources.

Working with UK businesses and voluntary organisation’s, our outward facing collaborative approach will ensure we are the first place to come to for reliable up to date information about Heartburn, Barrett’s and Oesophageal Cancer.

HCUK - Information Centre

All you need to know about Heartburn, Barrett's Oesophagus, Oesopageal Cancer. If you need support we can offer advice, please contact us on the "Ask our Doctor a Question" form, or you can join one of our Local Support Groups. You can also buy Heartburn Cancer UK Clothing and other HCUK Merchandise to help Raise Awarness and of course we would very much welcome a Donation to keep the charity able to carry on offering free advise and Raising Awareness, Changing the Future and Saving Lives.